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Interrupted Crosstalk between Natural Killer Cells and Anti-epidermal Growth Factor Receptor: A Possible Role in Hepatocellular Carcinoma Treatment Failure

[ Vol. 21 , Issue. 7 ]

Author(s):

Hadeer Abosalem, Shahenda Mahgoub *, Mohamed Emara , Nahla Kotb and Sameh SororPages 601-607 (7)

Abstract:


Hepatocellular carcinoma (HCC) is a major health problem worldwide. Most patients are diagnosed for the first time at late stages, which leads to very poor prognosis. It is challenging to discover strategies for treatment at these advanced stages. Recently, monoclonal antibodies (mAbs) targeting specific cellular signaling pathways in HCC have been developed. Unfortunately, they still have a low survival rate, and some of them failed clinically to produce effective responses even if they showed very good results against HCC in preclinical studies. This review focuses on and discusses the possible causes for the failure of mAbs, precisely anti-Epidermal Growth Factor Receptor (EGFR) mAb and the crosstalk between this mAb and patients' NK cells.

Keywords:

HCC immunotherapy, molecular target therapy, tumor microenvironment, NK, anti-EGFR mAb, ADCC.

Affiliation:

Biotechnology Unit, Egyptian Drug Authority (EDA), Giza, 12654, Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Department of Microbiology and Immunology, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo,11795, Manager of Blood Derivative Unit, Egyptian Drug Authority (EDA), Giza, 12654, Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795

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