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The Clinical Application of Circulating Tumor Cells and DNAs as Prognostic and Predictive Biomarkers in Gastrointestinal Cancer

[ Vol. 21 , Issue. 8 ]

Author(s):

Sara Memarpour*, Ghazaleh Khalili-Tanha*, Awa Alizadeh Ghannad, Masoud Sharifian Razavi, Mona Joudi, Marjan Joodi, Gordon A. Ferns, Seyed Mahdi Hassanian, Majid Khazaei and Amir Avan*Pages 676-688 (13)

Abstract:


Gastrointestinal (GI) cancer is one of the most common cancers globally. Genetic and epigenetic mechanisms are involved in its pathogenesis. The conventional methods for diagnosis and screening for GI cancers are often invasive and have other limitations. In the era of personalized medicine, a novel non-invasive approach called liquid biopsy has been introduced for the detection and management of GI cancers, which focuses on the analysis of Circulating Tumor Cells (CTCs) and circulating cell-free tumor DNA (ctDNA). Several studies have shown that this new approach allows for an improved understanding of GI tumor biology and will lead to an improvement in clinical management. The aim of the current review is to explore the clinical applications of CTCs and ctDNA in patients with GI cancer.

Keywords:

Gastrointestinal cancer, liquid biopsy, CTCs, ctDNA, biomarkers, tumor biology.

Affiliation:

Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Department of biological sciences, California state University, Sacramento, California, Department of Gastroenterology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Sarvar Children's Hospital, Endoscopic and Minimally Invasive Surgery Research Center, Mashhad, Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad

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