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Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy

[ Vol. 21 , Issue. 8 ]

Author(s):

Milad Ashrafizadeh, Md Shahinozzaman, Sima Orouei, Vahideh Zarrin, Kiavash Hushmandi, Farid Hashemi, Anuj Kumar, Saeed Samarghandian, Masoud Najafi* and Ali Zarrabi*Pages 640-665 (26)

Abstract:


Background: Lung cancer has the first place among cancer-related deaths worldwide and demands novel strategies in the treatment of this life-threatening disorder. The aim of this review is to explore the regulation of epithelial-to-mesenchymal transition (EMT) by long non-coding RNAs (lncRNAs) in lung cancer.

Introduction: LncRNAs can be considered as potential factors for targeting in cancer therapy, since they regulate a bunch of biological processes, e.g. cell proliferation, differentiation and apoptosis. The abnormal expression of lncRNAs occurs in different cancer cells. On the other hand, epithelial-to-mesenchymal transition (EMT) is a critical mechanism participating in migration and metastasis of cancer cells.

Methods: Different databases, including Google Scholar, Pubmed and Science direct, were searched for collecting articles using keywords such as “LncRNA”, “EMT”, and “Lung cancer”.

Results: There are tumor-suppressing lncRNAs that can suppress EMT and metastasis of lung cancer cells. Expression of such lncRNAs undergoes down-regulation in lung cancer progression and restoring their expression is of importance in suppressing lung cancer migration. There are tumor- promoting lncRNAs triggering EMT in lung cancer and enhancing their migration.

Conclusion: LncRNAs are potential regulators of EMT in lung cancer, and targeting them, both pharmacologically and genetically, can be of importance in controlling the migration of lung cancer cells.

Keywords:

Lung cancer, long non-coding RNA, epithelial-to-mesenchymal transition, metastasis, cancer therapy, microRNA, cadherin.

Affiliation:

Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956Istanbul, Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, Department of Genetics Science, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Laboratory for Stem Cell Research, Shiraz University of Medical Sciences, Shiraz, Department of Food Hygiene and Quality Control, Division of Epidemiology & Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Medical Technology Research Center, Institute of Health Technology, Kermanashah University of Medical Sciences, Kermanshah 6715847141, Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul

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