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Cellular Senescence-Inducing Small Molecules for Cancer Treatment

[ Vol. 18 , Issue. ]

Author(s):

Peng Liu, Yanfang Wu, Ziwen Lu, Dongsheng Shang, Zhicong Zhao, Yanting SHEN, Yafei Zhang, Feifei Zhu , Hanqing Liu and Zhigang Tu*Pages 1-11 (11)

Abstract:


Recently, the chemotherapeutic drug-induced cellular senescence has been considered a promising anti-cancer approach. The drug-induced senescence, which shows both similar and different hallmarks from replicative and oncogene-induced senescence, was regarded as a key determinant of tumor response to chemotherapy in vitro and in vivo. To date, an amount of effective chemotherapeutic drugs that can evoke senescence in cancer cells have been reported. The targets of these drugs differ substantially, including senescence signaling pathways, DNA replication process, DNA damage pathways, epigenetic modifications, microtubule polymerization, senescenceassociated secretory phenotype (SASP), and so on. By summarizing senescence-inducing small molecule drugs together with their specific traits and corresponding mechanisms, this review is devoted to inform scientists to develop novel therapeutic strategies against cancer through inducing senescence.

Keywords:

cancer, cellular senescence, small-molecular drugs, DNA damage responses, senescence-related signaling pathways

Affiliation:

Jiangsu University - Institute of Life Science Zhenjiang, Jiangsu, Jiangsu University - Institute of Life Science Zhenjiang, Jiangsu, Jiangsu University - School of Pharmacy Zhenjiang, Jiangsu, Jiangsu University - Institute of Life Science Zhenjiang, Jiangsu, Jiangsu University - School of Pharmacy Zhenjiang, Jiangsu, Jiangsu University - School of Pharmacy Zhenjiang, Jiangsu, Jiangsu University - School of Pharmacy Zhenjiang, Jiangsu, Jiangsu University - Institute of Life Science Zhenjiang, Jiangsu, Jiangsu University - School of Pharmacy Zhenjiang, Jiangsu, Jiangsu University - Institute of Life Science Zhenjiang, Jiangsu



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