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Regulation of MicroRNAs by Phytochemicals: A Promising Strategy for Cancer Chemoprevention

[ Vol. 18 , Issue. 7 ]

Author(s):

Sadegh Babashah*, Babak Bakhshinejad, Maryam Tahmasebi Birgani, Katayoon Pakravan and William C. Cho*Pages 640-651 (12)

Abstract:


A growing body of evidence suggests that phytochemicals are potentially able to affect a variety of cellular processes, including proliferation, apoptosis, cell-cycle control, angiogenesis, inflammation, and DNA repair. Phytochemicals may typically play pleiotropic regulatory roles in cancer cells. Chemoprevention, which can be achieved by using these natural agents, has emerged as a helpful strategy to manage a variety of malignancies. With regard to cancer-associated chemopreventive mechanisms, phytochemicals can act by modulating microRNAs (miRNAs) and their target genes. This review aims to present an overview of recent findings on the effects of some wellcharacterized bioactive phytochemicals on miRNA regulation in different cancer types. The potential use of these phytochemicals for the chemoprevention and treatment of cancer is also discussed.

Keywords:

Cancer, Chemoprevention, MicroRNA, Phytochemical, miRNA regulation, DNA repair.

Affiliation:

Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon

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