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Targeting Tumors with Small Molecule Peptides

[ Vol. 16 , Issue. 6 ]


Andrew G. Cheetham, Daniel Keith, Pengcheng Zhang, Ran Lin, Hao Su and Honggang CuiPages 489-508 (20)


Chemotherapeutic treatment of cancers is a challenging endeavor, hindered by poor selectivity towards tumorous tissues over healthy ones. Preferentially delivering a given drug to tumor sites necessitates the use of targeting elements, of which there are a wide range in development. In this Review, we highlight recent examples of peptide-based targeting ligands that have been exploited to selectively deliver a chemotherapeutic payload to specific tumor-associated sites such as the vasculature, lymphatics, or cell surface. The advantages and limitations of such approaches will be discussed with a view to potential future development. Additionally, we will also examine how peptide-based ligands can be used diagnostically in the detection and characterization of cancers through their incorporation into imaging agents.


Tumor targeting, cancer, peptides, ligands.


Department of Chemical and Biomolecular Engineering, and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, United States.

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