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Targeting Tumors with Small Molecule Peptides

[ Vol. 16 , Issue. 6 ]

Author(s):

Andrew G. Cheetham, Daniel Keith, Pengcheng Zhang, Ran Lin, Hao Su and Honggang CuiPages 489-508 (20)

Abstract:


Chemotherapeutic treatment of cancers is a challenging endeavor, hindered by poor selectivity towards tumorous tissues over healthy ones. Preferentially delivering a given drug to tumor sites necessitates the use of targeting elements, of which there are a wide range in development. In this Review, we highlight recent examples of peptide-based targeting ligands that have been exploited to selectively deliver a chemotherapeutic payload to specific tumor-associated sites such as the vasculature, lymphatics, or cell surface. The advantages and limitations of such approaches will be discussed with a view to potential future development. Additionally, we will also examine how peptide-based ligands can be used diagnostically in the detection and characterization of cancers through their incorporation into imaging agents.

Keywords:

Tumor targeting, cancer, peptides, ligands.

Affiliation:

Department of Chemical and Biomolecular Engineering, and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, United States.

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