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Current State of ERG as Biomarker in Prostatic Adenocarcinoma

[ Vol. 15 , Issue. 8 ]

Author(s):

Balazs Acs, Tibor Szarvas, Nora Szekely, Peter Nyirady and A. Marcell SzaszPages 643-651 (9)

Abstract:


In this review we briefly discuss the possible biomarkers of prostate cancer among them we focus and analyze the relevance of TMPRSS2-ERG fusion gene in line with ERG expression in the diagnosis of prostate cancer. Starting at diagnosis and genetic alterations in prostate carcinomas, we examine the incidence and detection of the most common genetic aberration in this tumor and its protein product as well. We also examined the correlation of clinicopathological factors and prognosis with ERG and the TMPRSS2-ERG fusion oncogene and ERG expression as predictive markers.

Keywords:

Diagnosis, ERG, prognosis, prediction, prostate carcinoma, TMPRSS2.

Affiliation:

2nd Department of Pathology, Semmelweis University Budapest, Address: 93 Ulloi ut, Budapest 1091, Hungary.

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